Liver, FGF21, and Appetite (IMAGE) Cell Press Caption Cravings for sweet foods are common, yet the mechanisms that influence the ''sweet tooth'' are not well-defined. This visual abstract depicts how in response to carbohydrate intake, the liver produces FGF21 to selectively suppress sugar appetite by acting on the PVN of the hypothalamus. Credit von Holstein-Rathlou and BonDurant et al/Cell Metabolism 2015 Usage Restrictions Credit Required. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.