Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP) (IMAGE)
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Figure 4. ADAM19 knockdown or inhibition alters secretory factors from senescent cells. (A) Heat map showing changes in the secretome composition from senescent IMR-90 cells with or without ADAM19 shRNA. (B-i) Venn diagram shows altered protein between ADAM 19 vs. IR and IR only groups. (B-ii) Venn diagram shows altered protein with cleavage motif in groups between ADAM 19 vs. IR and ADAM19 vs. control. (C) Protein network 12 commonly altered protein in groups between ADAM 19 vs. IR and IR.
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