Schematic representation of the wire-embedded 3D neural spheroid culture device, consisting of glass tube, agarose, PDMS, and Pt wire electrode. (IMAGE)
Caption
The agarose provided a low adsorption surface to form neural spheroid, and Pt wire electrode was pre-inserted to obtain interior signal recording without damage. The device allows for electrophysiology study from both interior and exterior of the neural spheroid and building neural tract connection model by employing simultaneous fading sinusoidal signals to stimulate 2 close neural spheroids. This platform has the potential to be expanded for use in various applications, including the internal supply of nutrients, real-time sensing, and organoids-based multi-brain region connection models.
Credit
Sumin Bian, School of Engineering, Westlake University.
Usage Restrictions
News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.
License
Licensed content