Excessive reactive nitrogen species (RNS) and reactive oxygen species (ROS) play a critical role in oxidative stress associated with aging and age-related diseases (IMAGE)
Caption
Excessive reactive nitrogen species (RNS) and reactive oxygen species (ROS), such as H2O2 (hydrogen peroxide), HO− (hydroxyl radical), HOO− (hidroperoxil), NO− (nitric oxide radical), NO2− (nitrogen dioxide radical), O2− (superoxide anion radical), and ONOO- (peroxynitrite anion), play a critical role in oxidative stress associated with aging and age-related diseases.
The accumulation of ROS causes messenger RNA (mRNA) damage, as well as lipid and protein oxidation, reduces mitochondrial function, and increases oxidative stress, contributing to the development of diseases such as dementia and cancer.
Credit
Mozaniel Santana de Oliveira
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