fig 1 (IMAGE)
Caption
The mutational spectrum of fibroblast growth factor receptor 3 (FGFR3) in individuals with achondroplasia. In humans, the mutations associated with achondroplasia patients are mainly located in transmembrane (TM) domain of FGFR3. The extracellular domain is referred to as ECD, while the intracellular domain is referred to as ICD. Heparan sulfate is represented by HS, and immunoglobulin-like domains are represented by I, II, and III. Tyrosine kinase domains are represented by TK.
Image link: https://ars.els-cdn.com/content/image/1-s2.0-S2352304224002332-gr1_lrg.jpg
Credit
Genes & Diseases
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License
CC BY-NC-ND