Macrophage ATF6 Accelerates Bone Remodeling in Orthodontic Tooth Movement. (IMAGE)

West China Hospital of Sichuan University

Macrophage ATF6 Accelerates Bone Remodeling in Orthodontic Tooth Movement.

Caption

This diagram illustrates the role of macrophage ATF6 in orthodontic tooth movement. When corticotomy is applied, monocytes are recruited to the bone, where they differentiate into pro-inflammatory macrophages. These macrophages activate ATF6, which then enhances the transcription of TNFα by binding to its promoter. This process accelerates osteoclast activity, promoting bone resorption and speeding up tooth movement. The diagram highlights key molecular interactions, including the activation of ATF6 and its interaction with the TNFα promoter.

Credit

International Journal of Oral Science

Usage Restrictions

Credit must be given to the creator.

License

CC BY

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.