A schematic diagram illustrates a proposed mechanism of interferon-γ (IFN-γ)-induced downregulation of tricellulin in salivary epithelial cells. (IMAGE)

West China Hospital of Sichuan University

A schematic diagram illustrates a proposed mechanism of interferon-γ (IFN-γ)-induced downregulation of tricellulin in salivary epithelial cells.

Caption

A schematic diagram illustrates a proposed mechanism of interferon-γ (IFN-γ)-induced downregulation of tricellulin in salivary epithelial cells. IFN-γ leads to the phosphorylation of signal transducer and activator of transcription 1 (STAT1) and then induces the upregulation of microRNA-145 (miR-145) which combines with tricellulin mRNA 3’ UTR and inhibits the expression of tricellulin. This would then cause the dysfunction of acinar epithelial barrier and the increased transports of macromolecules through paracellular pathway due to the loss of tricellulin in salivary glands, thereby resulting in hyposalivation. The schematic diagram is designed by Figdraw.

Credit

International Journal of Oral Science

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