NSD2-epigenomic reprogramming and maintenance of plasma cell phenotype in t(4;14) myeloma (IMAGE)
Caption
Figure 1: Transcriptional characterisation of KMS11 and TKO cells.
(A) Schematic of NSD2 status in KMS11 and TKO cells. (B) Western blot of histone expression. (C) Volcano plot of Log2 fold-change in RNA expression from KMS11 to TKO cells is plotted against -log10 P. Expression changes of >2-fold and significance P < 0.01 thresholds are shown with dotted line. (D) Heatmap of Piano analysis gene set consensus scores for KMS11 vs. TKO RNA expression. The consensus score is the mean rank given each gene set by the different GSA runs. A low score (e.g., 1) is a gene set that is ranked high by most of the GSA methods.
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