Male Slc3a1 KO mice exhibited severer stone formation and renal injuries. (IMAGE)
Caption
(A) Relative urinary cystine concentration of Slc3a1 KO and WT mice from both sexes. (B) Typical hexagonal cystine crystals from the urine of Slc3a1 KO and WT mice. Scale bar,100 μm. (C) Bladder stones in 20-week-old Slc3a1 KO mice from both sexes. (D) Serum blood urea nitrogen (BUN) and creatinine measurement of Slc3a1 KO and WT mice from both sexes. (E) Protein levels of KIM1 in the kidneys of Slc3a1 KO and WT mice from both sexes. (F) Relative mRNA levels of fibrosis and inflammatory genes (Col3a1, Vimentin, Fibronectin, IL-1β, and TNF-α) in the kidneys of Slc3a1 KO and WT mice from both sexes. (G) Representative images (left) of hematoxylin/eosin-, Sirius red-, and TUNEL-stained kidney sections of Slc3a1 KO and WT mice from both sexes and their quantification (right). Scale bar, 100 μm. All data are represented as mean ± standard error mean. p values were calculated by one-way ANOVA with the post hoc Tukey test. ∗∗∗∗p < 0.0001, ∗∗∗p < 0.001, ∗∗p < 0.01, ∗p < 0.05.
Credit
Genes & Diseases
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