CD47-null femoral fractures show reduced bone formation, but increased tissue mineral density. (IMAGE)

West China Hospital of Sichuan University

CD47-null femoral fractures show reduced bone formation, but increased tissue mineral density.

Caption

CD47-null femoral fractures show reduced bone formation, but increased tissue mineral density. µCT analysis of transverse femoral fracture in WT (n = 9) and CD47-null (n = 11-14) mice at 10- and 20-days post-fracture. Each data point represents an individual mouse. a Representative 3D reconstructions (white background) and sagittal-plane reconstruction (black background) of WT and CD47-null mice at days 10 and 20 post-fracture. Location of fracture (red arrowhead) is marked on the sagittal reconstructions. Representative 3D reconstructions include callus mineralization (teal). Quantitative assessments of various bone healing parameters determined by µCT (mean ± SD) at day 10 and 20 post-fracture. b Callus volume, c Bone volume, d bone mineral content, e Tissue mineral content, f Callus length, g Bone volume fraction, h. Bone mineral density, i Tissue mineral density. *P < 0.05, two-sided t test performed at each timepoint.

Credit

Bone Research

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