Model of tumor cell-derived ENO2 promoting macrophage M2 polarization and facilitating metastasis in HNSCC. (IMAGE)

Higher Education Press

Model of tumor cell-derived ENO2 promoting macrophage M2 polarization and facilitating metastasis in HNSCC.

Caption

Schematic representation depicts the mechanism by which the ENO2-derived oncometabolite PEP directly binds to HDAC1 and thereby promotes H3K18la, which promotes macrophage polarization and leads to metastasis in HNSCC (created with BioRender.com).

Credit

henran Wang et al.

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License

CC BY-NC-ND

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