Shisa7 expression in the orbitofrontal cortex was identified by machine learning as the gene signature reliably predictive of heroin use in human heroin users as compared to controls (IMAGE)

Elsevier

Shisa7 expression in the orbitofrontal cortex was identified by machine learning as the gene signature reliably predictive of heroin use in human heroin users as compared to controls

Caption

Overexpression of Shisa7 in the orbitofrontal cortex in drug-free rats induced comparable up and down changes in gene expression as that induced by the self-administration of heroin. The concordant overlapping transcriptional changes strongly related to neurodegenerative processes.

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Biological Psychiatry/Ellis et al.

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