R75W single-base mutation in the gap junction β2 (GJB2) gene causes syndromic hearing loss and lacks curative therapies (IMAGE)

Juntendo University Research Promotion Center

R75W single-base mutation in the gap junction β2 (GJB2) gene causes syndromic hearing loss and lacks curative therapies

Caption

Adeno-associated virus vector containing an adenine base editor provides an effective strategy to treat hereditary hearing loss caused by the R75W mutation. Moreover, this gene editing technology can be adapted in the future to target other deafness-causing mutations involving single-base substitutions.

Credit

Dr. Kazusaku Kamiya from Juntendo University, Japan

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