EBV Infection Aggravates Ulcerative Colitis via Glycolysis-Driven Macrophage Pyroptosist. (IMAGE)

West China Hospital of Sichuan University

EBV Infection Aggravates Ulcerative Colitis via Glycolysis-Driven Macrophage Pyroptosist.

Caption

Epstein-Barr virus infection induces the upregulation of glycolysis in intestinal macrophages, which subsequently activates Gasdermin D, NLRP3, interleukin-1β, and interleukin-18 in macrophages within colonic tissues. The release of these pro-inflammatory cytokines results in intestinal barrier dysfunction and exacerbates ulcerative colitis.

Credit

Precision Clinical Medicine

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CC BY

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