Selective G6PDH inactivation for Helicobacter pylori eradication with transformed polysulfide (IMAGE)
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Using the hydrothermal method, organic polysulfides in garlic were converted into the inorganic polysulfide hydrogen donor FepSM, which was further modified to prepare GAPSR for the adaptation to the acidic environment of stomach. This GAPSR achieves the eradication of Helicobacter pylori colonized in the stomach by slowly releasing inorganic polysulfide hydrogen, which targets Cys144 of H. pylori G6PDH.
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