Intervertebral disc (IMAGE)

Universitat Pompeu Fabra - Barcelona

Intervertebral disc

Caption

Structure and main ECM components of a non-degenerate, IVD (left) and a degenerate IVD (right). Within a non-degenerate human IVD the anabolic and catabolic components that regulate the ECM of the disc are kept in balance. During disc degeneration the balance is dysregulated, resulting in decreasing matrix synthesis of COL2A and ACAN and promotion of degrading enzymes (MMPs, ADAMTs). Regarding the disc morphology clear boundaries between NP and AF are difficult to distinguish with degeneration. Created with BioRender.com (2022).

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