A schematic of the role of intestinal CB1R in alcohol-induced leaky gut. (IMAGE)

First Hospital of Jilin University

A schematic of the role of intestinal CB1R in alcohol-induced leaky gut.

Caption

Alcohol binge increases intestinal permeability by activating intestinal epithelial CB1R-ERK1/2 signalling with subsequently reduced differentiation and downregulation of tight junctions (left). Genetic or pharmacological inhibition of intestinal CB1R-ERK1/2 signalling restored normal intestinal permeability and epithelial differentiation (right). Figure created with Biorender.com. CB1R, cannabinoid receptor 1; ERK1, mitogen-activated protein kinase 1/2.

Credit

By Luca Maccioni, Szabolcs Dvorácskó, Grzegorz Godlewski, Resat Cinar, Malliga R Iyer, Bin Gao and George Kunos.

Usage Restrictions

Credit must be given to the creator. Only noncommercial uses of the work are permitted.

License

CC BY-NC

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