Impact of circadian rhythm disorder on tumor progression and immune microenvironment (IMAGE)
Caption
On the one hand, circadian rhythm disorder contributes to tumor growth and metastasis by influencing the dysregulation of gene expression affecting the tumor itself. On the other hand, circadian rhythm disorder can also promote the formation of a suppressive immune microenvironment, reduce the number of natural killer (NK) cells and the M1/M2 ratio, and increase the CD4/CD8 ratio and the number of regulatory T (Treg) cells, thus indirectly promoting tumor progression. CD, cluster of differentiation; M1, pro-inflammatory; M2, anti-inflammatory.
Credit
Aimin Jiang, Linhui Wang, Jinxin Li, Peng Luo, Ying Liu
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CC BY-NC