Schematic representation of histone-modifying factor recruitment on cccDNA minichromosomes in relation to viral protein HBx. (IMAGE)
Caption
Schematic representation of histone-modifying factor recruitment on cccDNA minichromosomes in relation to viral protein HBx. In the presence of HBx, histone-modifying factors such as p300/CBP, Set1A, and HAT1 are activated and loaded onto cccDNA, resulting in an open configuration of the cccDNA minichromosomes. This open configuration allows viral gene transcription, which leads to a high level of viral replication. Conversely, in the absence of HBx, host restriction factors such as HDAC1, PRMT1, and SIRT3 are loaded onto cccDNA, resulting in a closed configuration of the cccDNA minichromosomes. This closed configuration leads to repression of viral gene transcription, resulting in a low level of viral replication. PRMT1, arginine methyltransferase 1; CBP, CREB binding protein; HDAC1, histone deacetylase 1; SIRT3, sirtuin 3; HAT1, histone acetyltransferase 1.
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Genes & Diseases
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