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Higher Education Press

Graphical Abstract

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Epstein-Barr virus infection induces the upregulation of glycolysis in intestinal macrophages, which subsequently activates Gasdermin D, NLRP3, interleukin-1β, and interleukin-18 in macrophages within colonic tissues. The release of these pro-inflammatory cytokines results in intestinal barrier dysfunction and exacerbates ulcerative colitis.

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Chunxiang Ma, Kexin Chen, Lili Li, Mingshan Jiang, Zhen Zeng, Fang Yin, Jing Yuan, Yongbin Jia, Hu Zhang

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