(IMAGE)

Genomic Press

Caption

Impact of CD2AP deficiency in microglia in Alzheimer’s disease (AD). Microglial CD2AP levels are increased in AD, leading to elevated CSF1R signaling and C1q expression and cytoskeleton remodeling in microglia, resulting in the formation of disease-associated microglia (DAM) and elevated microglial phagocytosis of synapses. CD2AP deficiency in microglia attenuated these changes to protect against AD.

Credit

Yun-wu Zhang

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