Epidemiology and genetic determination of measures of peripheral vascular health in the Long Life Family Study (IMAGE)
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Figure 2. Genomic region within the significant linkage peak for ABI in All LLFS participants. Fully adjusted LOD-scores on chromosome 15 from all three bins of mIBD estimates for linkage analyses of ABI in all participants. Significance and suggestive evidence of linkage are indicated by the horizontal dashed lines at LOD = 3.0 and LOD = 2.5, respectively. The peak reached its maximum LOD score at 11cM, and had a range of 6–16cM. This region maps to 26,267kb-31,213 kb on chromosome 15 and the 26 genes are located within this genomic region. They include GABRB3, GABRA5, GABRG3, OCA2, HERC2, GOLGA6L24, GOLGA8F, GOLGA8G, GOLGA6L25, GOLGA8M, GOLGA6L7, APBA2, ENTREP2, NSMCE3, TJP1, GOLGA8J, GOLGA8T, CHRFAM7A, GOLGA8R, GOLGA8Q, GOLGA8H, ARHGAP11B, ENSG00000284906, FAN1, MTMR10, and TRPM1 (as generated from the UCSC genome browser; GRCh38/hg38 accessed on August 14, 2023).
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