Figure 1 (IMAGE)

Institute for Basic Science

Figure 1

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Experimental setup for observational fear testing and calcium imaging in observer mice. The observer mouse witnesses the demonstrator mouse receiving electric shocks, enabling the assessment of observational fear. During the experiment, miniature endoscopic calcium imaging is used to monitor neuronal activity in the observer's anterior cingulate cortex (ACC). Green-labeled neurons indicate cells expressing calcium indicators (GCamp6f), while white-labeled neurons represent activated cells observed through calcium imaging (Raw). The observed behaviors in the observational fear experiment include observer freezing (OB-freezing; pink), demonstrator pain response (DM-reaction; blue), and demonstrator freezing (DM-freezing; yellow). Lastly, examples of GCamp6f signals from neurons associated with each behavior are presented.

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Institute for Basic Science

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