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Toward the goal of efficient editing of farm animals for genetic improvements, this study explores an upgraded form of nuclease PE (uPEn). Based on an initial demonstration of its success in editing mouse zyotes, uPEn was further employed to install two-site knock-in/knockout edits in Hu sheep. The robust performances of uPEn in sheep zygotes establishes it as a promising tool for livestock genetic improvements and beyond.
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Weijia Mao, Pei Wang, Lei Zhou, Dongxu Li, Xiangyang Li, Xin Lou, Xingxu Huang, Feng Wang, Yanli Zhang, Jianghuai Liu, Yongjie Wan
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