Schematic hypothesis. (IMAGE)

Chongqing Medical University

Schematic hypothesis.

Caption

Schematic hypothesis. Ischemic stroke causes iron accumulation, disrupting the redox balance, which in turn leads to two outcomes. One of the outcomes is the increased cell susceptibility to ferroptosis, accompanied by the accumulation of lipid reactive oxygen species (ROS). Additionally, the disrupted redox balance induces the phosphorylation of RIPK1, amplifying susceptibility to necroptosis.

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Genes & Diseases

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