Molecular Glue for the ChREBPα/14-3-3 PPI interaction (IMAGE)

The Mount Sinai Hospital / Mount Sinai School of Medicine

Molecular Glue for the ChREBPα/14-3-3 PPI interaction

Caption

Illustrating the mechanism by which small molecule stabilizers of the ChREBPα/14-3-3 protein-protein interaction (PPI) protect insulin-secreting beta cells from glucolipotoxicity. The optimized "molecular glue" compounds retain ChREBPα in the cytoplasm, preventing its transcriptional activity and subsequent beta cell dedifferentiation and death. This approach highlights a novel therapeutic strategy for maintaining beta cell identity and function in the context of type 2 diabetes.

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Mount Sinai Health System

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