siMecA-Exos protect mice from lethal MRSA infection (IMAGE)
Caption
siMecA-AGO2 complex inhibits the translation of the mecA gene which encodes the penicillin-binding protein 2a (PBP2a), a protein at the heart of the drug-resistance phenotype in MRSA. By reducing PBP2a levels by exosome-delivered siMecA-AGO2 complex, MRSA can be converted into methicillin-sensitive bacteria. Thus, coadministration of methicillin (i.p.) and siMecA-Exos (i.v.) effectively protected mice from lethal infection (70% survival rate).
Credit
Cell Reports Medicine
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