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Endothelial-to-Osteoblast Conversion (EC-to-OSB) regulates bone formation and homeostasis via the Kindlin-2/Piezo1/TGFβ/Runx2 axis. Reduced Kindlin-2 in endothelial cells increases Piezo1 stability to increasing bone mass. Targeting Kindlin-2 with mRNA editing boosts bone mass, offering potential osteoporosis treatment.

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Guixing Ma, Yingying Han, Wanze Tang, Bo Zhou, Litong Chen, Zhen Ding, Siyuan Cheng, Di Chen, Huiling Cao

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