The layers of complexity in postnatal mouse heart development using multi-omics and sequencing tools (IMAGE)

Tsinghua University Press

The layers of complexity in postnatal mouse heart development using multi-omics and sequencing tools

Caption

In the left part can be seen multi-omics analysis suggested some proteins (histone / non-histone), protein lactylation, and genes change significantly at different developmental stages (1 w [week], 6 w, 6 m [month], 12 m, and 14 m) of mouse heart. And in the right panel, the level of histone 4 lysine 12 lactylation (H4K12la) decreased during the development of mouse heart (from 1 w to 6 w). Then the change can regulate the downstream genes to affect some developmental processes. Art by Xiaodong Luan.

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Xiaodong Luan,Peking Union Medical College Hospital

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