Relationship between adipose CX3CL1 and BDNF (IMAGE)

Toho University

Relationship between adipose CX3CL1 and BDNF

Caption

This figure illustrates a putative relationship between adipose CX3CL1 and brain BDNF, and its age-related changes. In young mice, steroid hormones contribute to maintaining brain BDNF levels via adipose CX3CL1. However, in aged mice, a deficiency of adipose 11β-HSD1 leads to insensitivity to steroid hormones, which in turn decreases the expression of adipose CX3CL1 and subsequently reduces brain BDNF levels.

Credit

Dr. Yoshinori Takei

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