Dual-threshold categorizer for patient-centered circulating tumor DNA (ctDNA) concentration thresholding in metastatic breast cancer (mBC) for ctDNA risk-informed scheduling of clinical care (IMAGE)
Caption
Blood draws with <10 copies/mL [0.25% variant allele frequency (VAF)] indicate high negative predictive value (NPV; safe zone; green) for progression and could be used to postpone radiology and reassure patients. Concentrations >100 copies/mL (2.5% VAF; danger zone; red) indicate high positive predictive value (PPV) for progression within 12 weeks, and could trigger escalation to comprehensive genomic testing, multidisciplinary oncology consultations, and advance radiology. ctDNA levels between 10 and 100 copies/mL (0.25% and 2.5% VAF) represent a gray zone with no diagnostic power. Size of the color fields indicates relative proportion of blood draws in that result interval: green (53% to 58%), gray (14% to 20%), red (27%).
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The Journal of Molecular Diagnostics
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