The following schematic diagram illustrates the primary design concepts and the mechanism of action of the carrier in the study. (IMAGE)

Sichuan International Medical Exchange and Promotion Association

The following schematic diagram illustrates the primary design concepts and the mechanism of action of the carrier in the study.

Caption

AE-loaded PLGA nanoparticles were synthezied. IFN-γ activates the downstream signaling pathway through p-stat1 by recognizing its receptor and promotes the upregulation of key immune regulatory molecules in UMSCs, including IDO/PDL-1, to enhance their immune regulatory effects. AE further promotes the aforementioned process by promoting the phosphorylation of p-stat1. Meanwhile, the upregulation of HLA-II expression is inhibited by transfecting siCIITA, which prevents immune rejection of UMSCs in vivo. Ultimately, AE-I pretreated UMSCs exhibited significant therapeutic effects in the SAP model mice. Art by Yu Zou.

Credit

The author Yu Zheng

Usage Restrictions

Please cite the source.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.