fig 1 (IMAGE)

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fig 1 — Caption

The structures of human and mouse FAM20C. Human FAM20C consists of 584 amino acids (aa), with an N-terminal signal peptide (SP) composed of 22 aa, and a conserved C-terminal domain (CCD) composed of 350 aa. CCD contains a casein kinase (CK) domain ranging from residue 354 to 565. Mouse FAM20C consists of 579 aa, with an SP comprised of 26 aa and a CCD comprised of 350 aa. CCD also contains a CK domain ranging from residue 349 to 560. Furthermore, the structure of FAM20C contains a cleavage site, an integrin-bound tripeptide (arginine-glycine-aspartate, RGD), two Mn2⁺ binding sites, three N-glycosylation sites, and 11 cysteine residues. The stars represent eight cysteine residues that are conserved within different species.

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