Figure |Illustration of multifunctional nanoplatforms M@P inducing cancer cells pyroptosis and ferroptosis for cancer photoimmunotherapy. (IMAGE)
Caption
Figure | Illustration of multifunctional nanoplatforms M@P inducing cancer cells pyroptosis and ferroptosis for cancer photoimmunotherapy. Nanoplatforms M@P is constructed by self-assembly of photosensitizer MTCN-3 and immunoadjuvant Poly(I: C), which are further encapsulated in amphiphilic polymers. This resulting nanoplatform has the characteristics of cancer cell targeting and pH response. After targeting lysosomes, M@P can cause lysosome dysfunction through the generation of reactive oxygen species and heat under light irradiation, triggering pyroptosis and ferroptosis of tumor cells, achieving immunogenic cell death, and further enhancing immunotherapy through the combined effect with the immunoadjuvant Poly(I: C).
Credit
by Zhichao Wang, Yuqi Tang, and Quan Li
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CC BY