Commonly used prescription medications have a post-lanosterol biosynthesis inhibiting effect. (IMAGE)
Caption
Commonly used prescription medications have a post-lanosterol
biosynthesis inhibiting effect. Pathogenic variants in the DHCR7 gene result in SLOS with a hallmark sterol inhibition signature. This profile encompasses the accumulation of 7-DHC and 7-DHD and the reduction of desmosterol and cholesterol levels. Many commonly used prescription medications give rise to similar biochemical signatures and can be considered sterol biosynthesis inhibitors. The post-lanosterol pathway is greatly simplified for readability.
Credit
Károly Mirnics
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