Senolytic agent ABT-263 mitigates low- and high-LET radiation-induced gastrointestinal cancer development in Apc1638N/+ mice (IMAGE)
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Figure 6. ABT-263 dampens low- and high-LET radiation-induced oncogenic β-catenin signaling. (A) Representative micrographs of active-β-catenin immunostained intestinal tissue sections. (B) Representative micrographs of cyclinD1 immunostained intestinal tissue sections. (C) Quantification of active-β-catenin-stained images. Quantitative data presented as mean ± SEM, and * depicts a statistically significant difference (p<0.05) between the indicated groups. (D) Quantification of cyclin D1-stained images. Quantitative data presented as mean ± SEM and * depicts a statistically significant difference (p<0.05) between the indicated groups. (E) Schematic summary of mechanisms of ABT-263-mediated prevention of IR-induced GI tumorigenesis in Apc1638N/+ mice.
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