Time to clinical benefit for total MACE (IMAGE)
Caption
Time to clinical benefit was assessed. The x-axis represents time from randomization, and the y-axis represents the degree of benefit at that time, as measured by the hazard ratio shown in blue. The vertical black line marks the day that the treatment benefit of sotagliflozin reached and maintained statistical significance. Despite the SCORED trial enrolling stable patients, by just 3 months, there was already a significant decrease in heart attacks and strokes – a very early benefit that is generally not seen with medications used in non-acute settings.
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Mount Sinai Health System
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