A working model for peri-centrosomal localization of NRDE-3/siRNAs in C. elegans. (IMAGE)

Science China Press

A working model for peri-centrosomal localization of NRDE-3/siRNAs in C. elegans.

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Left: NRDE-3 localizes in nucleus in wild-type background. Right: The nuclear Argonaute protein NRDE-3 shows peri-centrosomal foci localization in eri-1, ergo-1, and drh-3 background. The process depending on NRDE-3 siRNA binding ability. NRDE-3-bound 22G RNAs map to the 3’ regions of the target genes.

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