A novel concept in redox pharmacology focusing on the metabolism of supersulfides. (IMAGE)

National Institutes of Natural Sciences

A novel concept in redox pharmacology focusing on the metabolism of supersulfides.

Caption

Reactive species such as reactive oxygen species (ROS), reactive nitrogen species (RNS) and environmental electrophiles react and form adduct with cysteine residues of proteins, leading protein dysfunction and exacerbating heart failure. In this study, we have discovered new concept of redox pharmacology that focuses on the supersulfidation of cysteine residues (Cys-SnSH; n≥1) to protect protein function using oxidized glutathione rather than GSH.

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Akiyuki Nishimura

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