Fig. 1 (IMAGE) Osaka University Caption Selenoproteins safeguard stemness of hematopoietic stem cells and B-lineage maturation. Disrupted selenoprotein synthesis recapitulated aged phenotype. The accumulation of lipid peroxidation accelerated by aging occurs in specific cellular contexts and lineages. Under such oxidative stress, B cell progenitors acquire myeloid characteristics. (Created in BioRender. Yamazaki, H. (2025) https://BioRender.com/ w92d562) Credit Yumi Aoyama Usage Restrictions Credit must be given to the creator. Only noncommercial uses of the work are permitted. License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.