MAP-JAG Juvenile Idiopathic Arthritis study including case study (VIDEO)
Caption
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I was diagnosed of juvenile idiopathic
arthritis when I was three years old.
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it was luckily, then, controlled
with just a joint injection
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and I was in remission
from then until around the age of ten.
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Juvenile idiopathic arthritis is a type
of childhood onset inflammatory arthritis.
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What that means is that children
experience inflammation
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where the immune system is active
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and it results in inflammation
occurring within the joints
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it's usually worse in the mornings
with things such as stiffness
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in my joints or struggling to, like,
get up out of chairs and out of bed.
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And then especially with pain in my hands,
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such as holding heavy objects
and things like that.
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One of the biggest challenges, actually,
in the treatment of children
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and young people with arthritis is,
achieving early and effective treatment
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for that we need to understand
which drugs will work for which child.
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One of the ways that we're doing
that is through the MAPJAG study,
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in which we perform synovial tissue
biopsies from the lining of the joint
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and performed in the ultrasound guidance
so that we can remove
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small amounts of tissue
from the lining of the joint
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at the same time the child is
undergoing a joint injection procedure.
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We then take those tissue samples
away to the lab for analysis to understand
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what's happening actually,
within the cells that are present
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within the lining of that joint,
and what that tells us about
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whether a child will respond
to a particular type of treatment or not.
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the first medication I was
on was methotrexate.
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However, it managed my condition well,
but the side effects meant
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it wasn't really worth it for me.
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I'm now on a current medication,
which is a lot
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better, doesn't make me sick,
and things like that.
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what's made this now possible
is the ability to perform those type
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of biopsies, using an ultrasound to guide
exactly where the needle is going.
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I think it's really important
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that the right research goes
into making sure that medications
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are found to people at the right time
in their treatment journeys.
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I'm currently working towards my grade
eight violent exam.
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with my wrists being painful.
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I also struggled with in class
on the right medication,
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and that requires a lot of,
strength and mobility with my hand.
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it wouldn't have been possible
without finding the right medication
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and managing to get
my condition under control.
Credit
2025, University of Birmingham
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