Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms (IMAGE)

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Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms

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Figure 2: Proposed treatment algorithm by HR status.

Our proposed treatment algorithm reflects a potential treatment option for HR+, HER2 ultralow metastatic breast cancer based on the results of DESTINY Breast-06. HR: hormone receptor; mBC: metastatic breast cancer; ET: endocrine therapy; CHT: chemotherapy; T-DXd: trastuzumab deruxtecan; SG: sacituzumab govitecan; ADCs: antibody drug conjugate; tx: treatment.

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© 2025 Hensing et al.

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