Comparative Strategies for Organoid Derivation: Mechanical vs. Enzymatic Dissociation. (IMAGE)

Tsinghua University Press

Comparative Strategies for Organoid Derivation: Mechanical vs. Enzymatic Dissociation.

Caption

The illustration highlights the strengths of mechanical dissociation in preserving the native tumor microenvironment and ensuring viability, alongside the advantages of enzymatic digestion for standardization, high-throughput applications, and gene editing. Combined approaches are tailored for specific tissue types, optimizing the generation of patient-derived organoids for advanced cancer research.

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Shichao Duan, Henan University People’s Hospital

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