Spatial cognitive function declines due to early age-related changes in the dentate gyrus of the hippocampus in RP58 heterozygous mice (IMAGE)
Caption
Left: In the dentate gyrus of the hippocampus of 4-5 month-old Rp58 heterozygous-KO mice, DNA damage accumulates in the mossy cells (yellow-green) (ssDNA; red), and the surrounding microglia (blue) are activated, showing a similar tissue image to that of old mice. ① Damaged mossy cells activate microglia (red arrow), and ② activated microglia further damage mossy cells (blue arrow) (hypothesis). As a result, signals from mossy cells to dentate gyrus granule cells, CA3 pyramidal cells, and CA1 pyramidal neurons are impaired, and ③ spatial cognitive ability declines.
Right: Chronic minocycline administration prevents age-associated changes in the hippocampal dentate gyrus and prevents a decline in spatial cognitive ability of 4-5 month-old Rp58 heterozygous-KO mice.
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