Graphical Abstract (IMAGE) Shanghai Jiao Tong University Journal Center Caption Summarizes recent advances in hydrogel bioelectronics for personalized healthcare, focusing on mechanical, electrical, acoustic, and optogenetic coupling. Discusses the latest progress in conductive polymers, particularly PEDOT:PSS, and their potential in decoupling electrical and mechanical properties. Discusses the concept of stimuli-responsive hydrogels that enable programmable deformation for targeted attachment and conformability to specific organs. Credit All authors (Chuan Wei Zhang, Chi Chen, Sidi Duan, Yichen Yan, Ping He & Ximin He) Usage Restrictions Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted. License CC BY-NC-ND Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.