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Higher Education Press

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The magic cube shows that multi-omics (transcriptome, DNA methylome and chromatin accessibility) form a highly interlinked network and play important but different roles together in cardiac development and pathology. The HCM heart demonstrates fetal gene reprogramming and inhibition of SP1 or EGR1 can alleviate the development of HCM in mice.

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Junpeng Gao, Mengya Liu, Minjie Lu4, Yuxuan Zheng, Yan Wang, Jingwei Yang, Xiaohui Xue, Yun Liu, Fuchou Tang, Shuiyun Wang, Lei Song, Lu Wen, Jizheng Wang

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