ART graphic (IMAGE)

PNAS Nexus

ART graphic

Caption

Assisted reproductive technologies (ART) can bypass female-modulated sperm selection (top of figure) that ensure that genetically compatible or competent sperm are used for fertilization. ART can also introduce a range of novel environmental stressors (bottom of figure) that generate epigenetic modifications in offspring. Failure to design procedures that both mimic natural conditions and mitigate the harmful effect of unnatural environmental conditions during ART can impact the health trajectories of ART offspring and potentially their descendants. 

Credit

Jonathan P. Evans and Francisco Garcia-Gonzalez

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