Besides EVs, saliva carries other particulate sources of miRNAs, such as lipoproteins. Commonly used one-step EV isolation protocols (such as UC and PEG or commercial kit precipitation) fail to remove all lipoproteins from EV preparations, which could act (IMAGE)

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Besides EVs, saliva carries other particulate sources of miRNAs, such as lipoproteins. Commonly used one-step EV isolation protocols (such as UC and PEG or commercial kit precipitation) fail to remove all lipoproteins from EV preparations, which could act

Caption

Besides EVs, saliva carries other particulate sources of miRNAs, such as lipoproteins. Commonly used one-step EV isolation protocols (such as UC and PEG or commercial kit precipitation) fail to remove all lipoproteins from EV preparations, which could act as  confounding factors in EV salivary biomarker studies, especially those focusing on miRNAs.

Credit

Tiago Degani Veit, Fernanda Visioli, José Artur Bogo Chies/Federal University of Rio Grande do Sul

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