Dedicator of cytokinesis 8 (DOCK8) mutation impairs the differentiation of helper T cells by regulating the glycolytic pathway of CD4+ T cells (IMAGE)

Sichuan International Medical Exchange and Promotion Association

Dedicator of cytokinesis 8 (DOCK8) mutation impairs the differentiation of helper T cells by regulating the glycolytic pathway of CD4+ T cells

Caption

DOCK8 mutation impairs the homeostasis of peripheral T cells, disrupts the development of Treg cells, increases ICOS expression in Tregs of the peripheral lymph nodes, promotes the differentiation of CD4+ T cells into Th17 cells, and upregulates the glycolytic levels in CD4+ T cells.

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Chaohong Liu

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