Ferroptosis and Intrinsic Drug-induced Liver Injury by Acetaminophen and Other Drugs: A Critical Evaluation and Historical Perspective (IMAGE)
Caption
Up to the 1980s, cell death caused by drugs, chemicals, and other pathophysiologies was primarily considered necrosis. This view radically changed with the discovery of apoptosis and its specific signaling pathways in the 1990s. By around 2000, apoptosis had become the prominent mode of cell death in liver diseases and other organ disorders. Despite this enthusiasm for apoptosis, there was limited concern that if this hypothesis were correct, potent pancaspase inhibitors could prevent all cell death and cure most diseases. As we know now, apoptosis is only relevant under specific circumstances, and we are still searching for therapies for most diseases. This may hint at what lies ahead as we navigate the (mostly erroneous) tendency to identify every cell death process in drug hepatotoxicity and other liver diseases as ferroptosis.
Credit
Hartmut Jaeschke, Anup Ramachandran
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License
CC BY-NC